| 抗CD123抗体靶向治疗急性髓系白血病 |
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| 引用本文： | 崔鹤1,张王刚2. 抗CD123抗体靶向治疗急性髓系白血病[J]. 现代肿瘤医学, 2015, 0(10): 1460-1463. DOI: 10.3969/j.issn.1672-4992.2015.10.41 |
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| 作者姓名： | 崔鹤1 张王刚2 |
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| 作者单位： | 1.内蒙古医科大学附属医院血液内科，内蒙古 呼和浩特 010050；2.西安交通大学第二附属医院血液内科，陕西 西安 710004 |
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| 基金项目： | 国家自然科学基金资助项目（编号:0817 18110232） |
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| 摘 要： | 白血病干细胞（leukemic stem cells,LSCs）被认为是白血病发生、发展、耐药、复发的根源，如何彻底根除LSCs已成为白血病治疗研究的一个重要方向。CD123是LSCs表面相对特异的抗原，针对其研发的靶向抗体治疗药物可有效杀伤急性髓系白血病（acute myeloid leukemia，AML）的LSCs，本文对抗CD123抗体靶向治疗AML的最新进展做一综述。
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| 关 键 词： | 抗CD123抗体 靶向治疗 急性髓系白血病 白血病干细胞 |
Targeted therapy with anti-CD123 antibody in acute myeloid leukemia |
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| Cui He1,Zhang Wanggang2. Targeted therapy with anti-CD123 antibody in acute myeloid leukemia[J]. Journal of Modern Oncology, 2015, 0(10): 1460-1463. DOI: 10.3969/j.issn.1672-4992.2015.10.41 |
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| Authors: | Cui He1 Zhang Wanggang2 |
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| Affiliation: | 1.Department of Hematology,the Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Hohhot 010050,China;2.Department of Hematology,the 2nd Affiliated Hospital,School of Medicine,Xi'an Jiaotong University,Shaanxi Xi'an 710004,China. |
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| Abstract: | Leukemia stem cells(LSCs) is considered to be the key of leukaemic occurrence,development,drug resistance and relapse.How to eradicate LSCs is an important research direction of leukemia treatment.CD123 is one of relatively specific antigens on the surface of the LSCs,many anti-CD123 antibodies can effectively kill acute myeloid leukemic(AML) stem cells.We described the current progress on targeted therapy with anti-CD123 antibody for acute myeloid leukemia in this article. |
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| Keywords: | anti-CD123 antibody targeted therapy acute myeloid leukemia leukemic stem cells |
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