子宫内膜异位症与卵巢癌相关性临床分析

目的:探讨子宫内膜异位症(内异症)与卵巢癌的相关性。方法:收集199例卵巢癌患者，分内异症组(n=32)，非内异症组（n=167），回顾性分析两组患者一般情况、临床表现、病理特征、实验室检查及预后。结果:内异症组平均年龄明显小于非内异症组(P＜0.05)，年龄<50岁、未生育患者构成比明显高于非内异症组；内异症组患者临床症状以月经改变和下腹痛、腹胀为主（P＜0.05）；内异症组肿瘤直径通常小于20cm,且主要在10-20cm之间，非内异症组肿瘤直径大部分为10-20cm；内异症组患者血CA125主要在200-1000kU/L之间，非内异症组大部分在200kU/L以下；内异症组患者以透明细胞癌、宫内膜样癌为主，非内异症组以浆液性囊腺癌为主(P＜0.05)；内异症组患者分期较早，I期 、Ⅱ期占合并卵巢癌患者68.8%，非内异症组分期多处于Ⅱ期、Ⅲ期，占原发卵巢癌患者70.1%（P＜0.05）；内异症组患者病灶部位多位于左侧卵巢,非内异症组病灶部位在左侧、右侧、双侧分布较接近 (P＜0.05)；内异症组5年生存率为59.4%,非内异症组5年生存率为34.7%,两组差异具有统计学意义(P＜0.05)。结论:应充分了解内异症恶变的临床症状及病理特征，提高早期诊断率。

Association of endometriosis and ovarian cancer

Objective:To investigate the association of endometriosis and ovarian cancer.Methods:All 198 cases with ovarian cancer were divided into endometriosis group(n=32),non endometriosis group(n=167),patients' general character,clinical manifestations,pathology,laboratory examination and prognosis were analysised.Results:The average age of endometriosis group was obviously less than that of non endometriosis group (P＜0.05),age<50 years old and unmarried patients in endometriosis group were more than that in non endometriosis group;clinlcal symptom were mostly abdominal pain,abdominal distension and menstrual (P＜0.05).Tumor diameter were usually less than 20cm，that in non endometriosis group were 10-20cm.CA125 were mainly in range of 200-1000kU/L,That in non endometriosis group were mostly below 200kU/L.Tumour types were mostly clear cell carcinoma,endometrioid carcinoma，that in non endometriosis group were mainly serous cystadenocarcinoma；tumor staging were mostly stage I,stage Ⅱ accounted for 68.8%，that in non endometriosis group were mostly stage II,III accounted for 70.1% (P＜0.05);lesions located mostly in left ovary，that in non endometriosis group were mostly close in left,right,bilateral distribution (P＜0.05);5 year survival rate was 59.4%，that in non endometriosis group was 34.7%(P＜0.05).Conclusion:Clinicians should give priority to prevention,fully understand clinical symptoms and pathological characteristics of malignant transformation of endometriosis,to improve early diagnosis rate.