TNFAIP3和GRP78表达与鼻咽癌组织放疗敏感的相关性

目的:探讨TNFAIP3及GRP78在放射治疗鼻咽癌中的表达，研究其在放射治疗鼻咽癌中的意义。方法:取60例2006年1月13日-2006年11月26日第1次入院放射治疗的鼻咽癌患者，运用原位杂交方法检测放射治疗鼻咽癌中TNFAIP3及GRP78 mRNA的表达。结果:放疗敏感及放疗抗拒鼻咽癌中，TNFAIP3 mRNA中度及强阳性表达率分别为15.00%和45.00%，GRP78 mRNA中度及强阳性表达率分别为20.00%和47.50%，差异有统计学意义。放疗抗拒鼻咽癌中，TNFAIP3 mRNA中度及强阳性表达率与TNM分期呈正相关，III-IV期表达率为48.28%，I-II期表达率为36.36%。GRP78 mRNA中度及强阳性表达率与TNM分期呈正相关，III-IV期表达率为58.62%，I-II期表达率为18.18%，与T分期呈正相关，T3-T4期表达率为68.42%，T1-T2期表达率为28.57%。在有、无远处转移中，TNFAIP3 mRNA中度及强阳性表达率分别为81.81%和31.03%，GRP78 mRNA中度及强阳性表达率分别为72.73%和37.93%，差异有统计学意义。结论:TNFAIP3、GRP78参与了放疗抗拒鼻咽癌的发生和发展。

Expressions of TNFAIP3 and GRP78 gene in radiotherapy of nasopharyngeal carcinoma

Objective:To study the expressions of TNFAIP3 and GRP78 in the radiotherapy of nasopharyngeal carcinoma，as well as their significances.Methods:Radiotherapies were taken in 60 cases of nasopharyngeal carcinoma，in situ hybridization detections were carried out to detect the expression of TNFAIP3 and GRP78 mRNA.Results:In radiosensitivity and radioresistance of nasopharyngeal carcinoma,the moderately and strongly positive TNFAIP3 mRNA expression rates were 15.00% and 45.00%，the moderately and strongly positive GRP78 mRNA expression rates were 20.00% and 47.50%,there were statistical significances.In the radioresistance of nasopharyngeal carcinoma，TNFAIP3 and GRP78 mRNA moderately and strongly positive expressions were positively correlated with TNM stage.