Tenascin-C在肾透明细胞癌中的表达及意义

目的:分析Tenascin-C（TN-C）在肾透明细胞癌中的表达及其与临床病理因素间的关系。方法:应用免疫组化方法检测肾透明细胞癌中TN-C蛋白表达情况。结果:免疫组化结果显示40.63%（39/96）的病例存在肿瘤间质TN-C蛋白的过表达，且过表达与肿瘤组织核分级负相关（P=0.022）；18.75%（18/96）的病例存在肿瘤细胞胞质TN-C蛋白的过表达，且过表达与肿瘤组织核分级、p-TNM分期正相关，分别为（P＜0.001；P=0.038）。肿瘤间质及肿瘤细胞胞质的过表达与RCCC患者的年龄、性别、肿瘤大小均无明显相关性。结论:肾透明细胞癌中存在TN-C蛋白肿瘤间质及肿瘤细胞的过表达，并与肿瘤分化和p-TNM分期相关。

The express and significance of Tenascin-C in renal clear cell carcinoma

Objective:To detect the expression of Tenascin-C（TN-C） in renal clear cell carcinoma (RCCC) and analyze the relationship between its expression and clinical pathological factors.Methods:Immunohistochemistry method was employed to evaluate protein levels of TN-C in RCCC.Results:TN-C expression was observed in the cytoplasm compartments of tumor cells and tumor stroma,while normal renal tissues exhibited negative or weak expression.For 96 RCCC tissues,strong staining of TN-C in RCCC stroma was observed in 40.63% of cases(39/96).This overexpression negative correlated with Fuhrman nuclear grade (I & II vs III & Ⅳ,P=0.022) At the same time,TN-C overexpression in RCCC tumor cells was observed in 18.75% cases (18/96).Its overexpression correlated with Fuhrman nuclear grade (I & II vs III & Ⅳ,P＜0.001)and patients with high Rsf-1 expression had advanced stage of RCCC (I & II vs III & Ⅳ,P=0.038).There was no statistical difference between TN-C overexpression and age,gender,tumor size.Conclusion:There was protein overexpression of TN-C in RCCC.Strong TN-C overexpression correlated with differentiation and p-TNM stage of RCCC.