重组人生长激素对老年肿瘤营养不良患者的营养状况和免疫功能的影响

目的:观察重组人生长激素(rhGH)对老年肿瘤营养不良患者的营养状况、免疫功能、蛋白质代谢等方面的作用和影响。方法:108例老年肿瘤营养不良患者随机分成两组，对照组54例，给予标准的营养支持治疗；治疗组(rhGH)54例，在对照组标准营养治疗基础上，加用rhGH。所有患者均于入院时和治疗后第14天，测量肱三头肌皮褶(TSF)厚度、测定微量空腹血糖(FBG)、糖化血红蛋白(HbAlc)水平、测定外周血清白蛋白(ALB)、转铁蛋白(TRF)、前清蛋白(PAB)、肌酐（Cre）、尿素(BUN)、TNF-α、IL-1、IL-6、免疫球蛋白(IgA、IgM、IgG)、外周血T细胞亚群(CD3+、CD4+、CD4+/CD8+)比例的变化。结果:治疗组与对照组相比，营养状况指标TSF厚度、ALB、TRF、PAB均明显增加(P<0.05)，Cre、BUN均明显减少(P<0.05)，炎症反应指标TNF-α、IL-1、IL-6均明显减少(P<0.05)，免疫功能指标(免疫球蛋白IgA、IgM、IgG)、T细胞亚群(CD3+、CD4+、CD4+/CD8+)比例均明显增加(P<0.05)。结论:rhGH 在老年肿瘤营养不良患者的营养状况、免疫功能和蛋白质代谢水平方面具有较好的作用。

Influence of recombinant human growth hormone on the nutritional status and immune function in acute exacerbation of malnutrition in elderly cancer patients

Objective:To investigate the effects of recombinant human growth hormone(rhGH） on the nutritional status,immune function and protein metabolism in malnutrition in elderly cancer patients．Methods:All 54 patients with malnutrition in elderly cancer patients who received standard nutritional support were enrolled as control group.54 patients with malnutrition in elderly cancer patients who received standard nutritional support and rhGH were included as treatment group.All subjects received antiinfection therapy，phlegmexpelling formula,brochodilators.The levels of TSF,ALB,TRF,PAB,Cre,BUN,TNF-α,IL-1,IL-6,IgA,IgM,IgG were observed before and 14 days after treatment,also T-cell subsets,such as CD3+，CD4+，CD4+/CD8+.Results:Compared with control group,subjects in treatment group had a significant increase in TSF,ALB,TRF,PAB and Cre,BUN were markedly lower than those of control group(P<0.05).TNF-α,IL-1,IL-6 were markedly lower than those of control group too(P<0.05).The IgA,IgM,IgG and T-cell subsets,such as CD3+,CD4+,CD4+/CD8+ were higher in treatment group(P<0.05).Conclusion:rhGH could induce better nutritional status,immune function and protein metabolism in malnutrition in elderly cancer patients.