GnRH-a对子宫内膜非典型增生的治疗价值

目的:探讨GnRH-a在子宫内膜非典型增生（AEH）中的治疗价值。方法:将66 例子宫内膜非典型增生患者按照随机的原则分为2组，A组患者（32 例）使用GnRH-a(诺雷德)治疗，每月一次，连用6个月。B组患者（34例）使用孕激素(醋酸甲羟孕酮)连续治疗6个月。每3个月行宫腔镜检查，并行内膜活检,记录结果并进行统计学分析。结果:两组轻中度非典型性增生治疗效果，无统计学意义（P>0.05）。重度非典型增生治疗效果GnRH-a组低于孕激素组，P<0.05，有统计学意义。两组总的治疗效果比较，无统学意义（P>0.05）。结论:GnRH-a用于治疗子宫内膜非典型增生效果与醋酸甲羟孕酮相似，具有每月一次的方便性，但价格较贵。

The value of GnRH - a in treatment of endometrial atypical hyperplasia

Objective:To investigate the value of GnRH-a in the treatment of endometrial atypical hyperplasia（AEH).Methods:All 66 cases of endometrial atypical hyperplasia patients were randomly divided into 2 groups.The patients in group A（32 cases） were treated with GnRH-a for 6 months.Patients in group B（34 cases） were treated with progesterone therapy for 6 months.Hysteroscopy examination and endometrial biopsy were applied every three months.Results:Among the patients with mild to moderate atypical hyperplasia，there was no statistical difference in the therapeutic effect between the two groups(P>0.05),while GnRH-a was not as effective as progesterone in the treatment of severe endometrial atypical hyperplasia(P<0.05).There was no statistical difference between the therapeutic effect of the two groups overall(P>0.05).Conclusion:The therapeutic effect of GnRH-a was similar to that of medroxyprogesterone acetate in the treatment of endometrial atypical hyperplasia.