氨基酮戊酸光动力疗法联合手术治疗皮肤基底细胞癌的疗效观察

目的:分析手术联合5-氨基酮戊酸光动力疗法（ALA-PDT)治疗皮肤基底细胞癌的临床疗效。方法:皮肤基底细胞癌患者30例，按抛硬币法分为观察组和对照组，每组15例。观察组患者于术前开始进行ALA-PDT治疗,每周1次,共3-7次,然后进行手术治疗,对照组患者只采取手术切除，随访16-25个月。比较两组治疗一期愈合率、有效率，并评价疗效。结果:观察组患者总有效率为100％（15/15），对照组总有效率为86.7％（13/15)，差异无统计学意义（P>0.05）。两组治疗一期愈合率、不良反应率差异具有统计学意义（P<0.05），观察组优于对照组。结论:手术联合ALA-PDT治疗皮肤基底细胞癌具有有效、安全等优点。

Clinical efficacy of aminolevulinic acid photodynamic therapy combined with surgical treatment on basal cell carcinoma

Objective:To analyse the clinical efficacy of surgery combined with 5-aminolevulinic acid-photodynamic therapy（ALA-PDT) treatment on basal cell carcinoma.Methods:Thirty basal cells cancer patients were divided into observation group and control group，15 cases in each group.In observed group patients before surgery were treated by ALA-PDT treatment once a week，a total of 3-7 times，then surgical treatment and control group patients only take surgery，follow-up for 16 to 25 months.Results:The total effective rate of the observation group was 100%（15/15),in the control group，the total effective rate was 86.7%（13/15)（P>0.05).Healing rates，adverse reaction rates were statistically significant different（P<0.05)，the observation group was better than the control group.Conclusion:Surgery combined with ALA-PDT treatment for basal cell carcinoma is effective and safe.