缺失基因DLC-1在原发性肝癌中的表达及意义

目的:探讨缺失基因DLC-1在原发性肝癌组织中的表达及与临床病理因素的关系。方法:采用免疫组化法研究60例肝癌中DLC-1的表达水平，观察评估DLC-1的阳性表达与肿瘤分级、淋巴结转移等临床病理因素的相关性。结果:60例原发性肝癌组织中，DLC-1高表达38例，癌旁组织高表达57例，两者差异有统计学意义（P<0.001)。肝癌分期越高，DLC-1 mRNA表达越低（P=0.008)。有淋巴结转移者DLC-1 mRNA表达也明显低于无转移者（P=0.012)。结论:缺失基因DLC-1与原发性肝癌的分期及侵袭转移能力密切相关，在肝癌发生、发展过程中起着重要的作用。

Clinical significance of DLC - 1 expression in hepatic cancer

Objective:To study the gene of deleted on liver cancer 1 （DLC-1） expression in primary liver cancer-tissues and its relationship with clinical pathological factors.Methods:To research immunized group 60 cases of hepatocellular carcinoma expression level of DLC-1，and the relation of DLC-1 expression and tumor grade，lymph node metastasis and clinical pathologic factors of relevance.Results:In 60 cases of primary liver cancer tissues，38 cases were high expression，adjacent tissues to carcinoma high expression were 57 cases (P<0.001).Along with the staging of liver cancer，DLC-1 was reduced （P=0.008).Low expression of DLC-1 was also corelated with lymph node metastasis （P=0.012).Conclusion:DLC-1 expression was downregulated in hepatic cancer tissues，and it's related to hepatic cancer and metastasis.