High bone turnover and accumulation of osteoid in patients with neurofibromatosis 1期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

High bone turnover and accumulation of osteoid in patients with neurofibromatosis 1

Authors:	S. Seitz C. Schnabel B. Busse H. U. Schmidt F. T. Beil R. E. Friedrich T. Schinke V. F. Mautner M. Amling

Affiliation:	(1) Center for Biomechanics & Skeletal Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany;(2) Department of Trauma, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany;(3) Department of Surgery, University of Munich (LMU), Munich, Germany;(4) Department of Clinical Chemistry, Center of Clinical Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;(5) Center of Orthopedics Wandsbek, Hamburg, Germany;(6) Department of Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Abstract:	Summary Although it is known that neurofibromatosis 1 (NF1) patients suffer from vitamin D deficiency and display decreased bone mineral density (BMD), a systematic clinical and histomorphometrical analysis is absent. Our data demonstrate that NF1 patients display high bone turnover and accumulation of osteoid and that supplementation of vitamin D has a beneficial effect on their BMD.

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