| 周围神经细胞外基质在神经再生中的研究进展 |
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| 引用本文： | 高旭鹏,彭江,孙逊,郭志远,王玉,赵庆,卢世璧. 周围神经细胞外基质在神经再生中的研究进展[J]. 军医进修学院学报, 2014, 35(9): 970-973 |
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| 作者姓名： | 高旭鹏 彭江 孙逊 郭志远 王玉 赵庆 卢世璧 |
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| 作者单位： | 解放军总医院骨科研究所,北京,100853 |
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| 基金项目： | 国家自然科学基金项目，国家高技术研究发展计划(863)课题，全军十二五重点项目，the National Natural Science Foundation of China，The National High Technology Research and Development Program of China，The 12th Five Years Programs of Chinese PLA |
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| 摘 要： | 细胞外基质（extracellular matrix,ECM）是指自然发生沉积在细胞周围的大分子物质,其为细胞提供结构支撑和黏附位点,并在细胞黏附、迁移、增殖、分化和基因表达中起重要的信号传递作用.周围神经细胞外基质成分主要包括胶原（Ⅰ,Ⅲ,Ⅳ,Ⅴ）、层粘连蛋白、纤连蛋白、硫酸软骨素及其他神经因子,其组成和特点表现出了细胞外基质成分作为神经修复材料的优越性.本文对周围神经来源的细胞外基质在构建组织工程神经方面的研究进展进行综述.
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| 关 键 词： | 细胞外基质 周围神经 神经再生 |
Advances in ECM-induced peripheral nerve regeneration |
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| GAO Xu-peng,PENG Jiang,SUN Xun,GUO Zhi-yuan,WANG Yu,ZHAO Qing,LU Shi-bi. Advances in ECM-induced peripheral nerve regeneration[J]. Academic Journal of Pla Postgraduate Medical School, 2014, 35(9): 970-973 |
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| Authors: | GAO Xu-peng PENG Jiang SUN Xun GUO Zhi-yuan WANG Yu ZHAO Qing LU Shi-bi |
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| Affiliation: | (Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China) |
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| Abstract: | Extracellular matrix （ECM） refers to the naturally occurring macromolecular substrate around cells that provides a support structure and an attachment site for cells, and plays an important role in transferring the signals of cell adhesion, migration, proliferation, differentiation and gene expression. The major compositions of ECM include collagens （ Ⅰ , Ⅲ, Ⅳ , Ⅴ ）, laminin, fibronectin, chondroitin sulfate proteoglycans and other nerve factors, and ECM is characterized by its advantages as a nerve repair material. Following is a review of the advances in tissue engineering nerve construction with peripheral nerve-derived ECM. |
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| Keywords: | extracellular matrix peripheral nerve nerve regeneration |
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