578例梅毒相关检测阳性患者分布情况分析

目的 了解梅毒相关检测阳性患者的分布,分析梅毒易感人群所在,为预防和治疗梅毒提供依据.方法 对我院2013年进行梅毒螺旋体明胶颗粒凝集试验（treponema pallidum particle assay,TPPA）及血浆反应素环状卡片试验（ring card test of plasma regain,RPR）联合检测的标本中,578例TPPA阳性标本按照年龄、性别、就诊类型、科室的分布进行统计学分析,对于二者联合检测为双阳性的患者根据RPR检测的滴度分布进行统计学分析.结果 578例TPPA阳性患者中,男性295例（51.0％）,女性283例（49.0％）,性别差异无统计学意义（P＞0.05）;门诊490例（84.8％）,住院88例（15.2％）,二者差异有统计学意义（P＜0.05）;年龄主要分布在21～40岁,但血清学反应阳性检出率以≤20岁区间最高,为92.6％,与其他年龄组比较差异有统计学意义（P＜0.05）;科室主要分布在皮肤科门诊.联合检测双阳性患者437例（符合率75.6％）.按照RPR检测滴度分布从1∶1至1∶128不等,患者人数随滴度升高而减少.结论 梅毒感染人群主要分布于中青年,也存在一定比例的梅毒患儿以及老年患者.就诊类型以门诊居多,尤其是皮肤科门诊.阳性确诊病例分布以低滴度患者较为集中.对以上易感人群加强梅毒预防知识教育,进行及时有效的追踪检测对控制梅毒的大范围传播具有重要的意义.

Distribution of 578 patients with positive detection of syphilis

Objective To analyze the distribution of patients with positive detection of syphilis and syphilis susceptible populations, and then provide basis for prevention and treatment of syphilis. Methods Clinical data （including age, sex, type of treatment and department） about 578 treponema pallidum particle assay （TPPA） positive cases who underwent combined detection of TPPA and ring card test of plasma regain （RPR） in our hospital in 2013 were analyzed and then RPR titers distribution of patients who showed double positive after combined detection was analyzed. Results Of the 578 TPPA positive patients, 295 cases were male （5 1.0%） and 283 cases were female （49.0%）, and there was no statistically significant difference of gender （P 〉 0.05）. 490 cases were outpatient （84.8%） and 88 cases were inpatient （15.2%）, and it showed statistically significant difference （P 〈 0.05）. The age range of 578 TPPA positive patients was 21 to 40 years old, and the highest positive rate of serologic reaction was in 20 years old or less group （92.6%）, the difference showed statistical significance comparing with other age groups. The department of 578 TPPA positive patients was mainly distributed in the outpatient of dermatology, and 437 cases （coincidence rate, 75.6%） showed double positive detected by combined detection. The distribution of RPR titer was 1 ： 1 to 1 ： 128, and the number of patients decreased with the increase of titers. Conclusion According to the analysis of the susceptible population, syphilis infection mainly exists in young and middle-aged patients, some are children or elder. The patients are mainly distributed in the outpatient, especially in the dermatology department. The distribution of positive cases concentrates in patients with low titer. Prevention knowledge education about syphilis should be strengthened and timely and effective tracking detection should be made in the syphilis crowd, which is of significant importance in control of widespread of syphil