Nicotine-11C: Synthesis and distribution kinetics in animals |
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| Authors: | Mariannick Mazière Dominique Comar Christian Marazano Gérard Berger |
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| Affiliation: | (1) Département de Biologie, Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, F-91406 Orsay, France |
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| Abstract: | In order to study  in vivo the distribution kinetics of (-)-nicotine in animals, this molecule was labeled with carbon-11. Two synthesis methods are described. Immediately after intravenous administration of (-)-nicotine-methyl-11C in rabbits the gamma-camera shows a strong radioactivity build-up in the brain and kidneys. The biological interest of this carbon-11 labeled molecule is discussed. |
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