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Disease profile of 400 institutionalized mentally retarded patients in Kuwait |
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| Authors: | T. I. Farag S. A. Al-Awadi M. H. El-Badramary M. A. Aref B. Kasrawi D. S. Krishna Murthy M. Y. El-Khalifa G. Yadav M. J. Marafie L. Bastaki R. A. Wahba F. M. Mohammed S. Abul Hassan A. A. Redha M. A. Redha H. Al-Aboud S. Al-Hijji D. Al-Dighashem N. Al-Hashash L. Al-Jeryan H. Al-Khorafi E. A. Qurban I. Al-Sulaiman |
| Affiliation: | Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait |
| Abstract: | Farag TI, Al-Awadi SA, El-Badramary MH, Aref MA, Kasrawi B, Krishna Murthy DS, El-Khalifa MY, Yadav G, Marafie MJ, Bastaki L, Wahba RA, Mohammed FM, Abul Hasan S, Redha AA, Redha MA, Al-aboud H, Al-Hijji S, Al-Dighashem D, Al-Hashash N, Al-Jeeryan L, Al-Khor-afi H, Qurban EA, Al-Sulaiman I. Disease profile of 400 institutionalized mentally retarded patients in Kuwait. Clin Genet 1993: 44: 329–334. © Munksgaard, 1993 In this preliminary report we summarize the results of a 4-year multidisciplinary systematic, etiological clinicogenetic survey of 400 institutionalized mentally retarded patients in Kuwait. All had an intelligence quotient below 50. A constitutional disorder, as the direct cause of the mental retardation, was found in 203 patients (50.75%)): a chromosomal abnormality in 37 (9.25%), Mendelian disorders in 137 (34.25%), MCA/MR in 22 (5.55%) and CNS malformations in 7 cases (1.75%). In 157 patients (39.35%) a pre-, peri or postnatal cause was ascertained. No etiological diagnosis was detected in 40 patients (10%). A detailed analysis of the "disease profile" is given and compared with the results of previous diagnostic genetic surveys among different institutionalized mentally retarded populations in Western and developing countries. |
| Keywords: | consanguinity disease profile mental retardation survey |