Comparative study of macrophage response in mice after DNA immunization and infection with herpes simplex virus type 1 |
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| Authors: | E V Nagurskaya L G Zaitseva N V Kobets I V Kireeva V A Bekhalo A Yu Kozlov R R Klimova S V Gur’yanova T M Andronova L N Shingarova E F Boldyreva O V Nekrasova |
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| Institution: | (1) N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Russia;(2) D. I. Ivanovskii Institute of Virology, Russian Academy of Medical Sciences, Russia;(3) M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow |
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| Abstract: | Functional activity of macrophages and intensity of T cell immune response in mice were studied after intravaginal and intraperitoneal
infection with herpes simplex virus type 1 and DNA vaccination in combination with adjuvant treatment (recombinant granulocytemacrophage
colony-stimulating factor and glucosaminylmuramyl dipeptide). DNA vaccination induced a virus-specific T cell immune response
with no macrophagic inflammatory reaction. Infection with herpes simplex virus type 1 was accompanied by sustained inflammation,
but not by the T cell immune response.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 140, No. 12, pp. 670–673, December, 2005 |
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| Keywords: | herpes simplex virus type 1 vaccination inflammation macrophages T cells |
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