MRI在新生儿急性胆红素脑病诊断中的价值

目的:探讨T1WI信号强度在新生儿急性胆红素脑病诊断中的价值。方法:对59例皮肤黄染新生儿行颅脑MRI检查,根据血总胆红素水平分为组Ⅰ、Ⅱ、Ⅲ、Ⅳ,测量并比较4组间双侧苍白球T1WI、T2WI信号强度。结果:①肉眼观察,组Ⅳ中6例患儿左、右侧苍白球T1WI信号明显升高,T2WI信号强度无明显差异。②经统计学分析,各组左、右侧苍白球T1WI信号强度差异无统计学意义(P>0.05),组Ⅳ双侧苍白球T1WI信号强度测量值较其余各组明显增高(P<0.05);组Ⅲ双侧苍白球T1WI信号强度测量值较组Ⅰ、Ⅱ明显增高(P<0.05);组Ⅰ、组Ⅱ之间差异无统计学意义(P>0.05)。4组间苍白球T2WI信号强度、eADC、ADC值差异无统计学意义(P>0.05)。结论:苍白球T1WI对称性信号增高是新生儿急性胆红素脑病的重要特征,并与血清胆红素水平密切相关。

The value of T1 WI signal intensity in the diagnosis of neonatal acute bilirubin encephalopathy

Objective： To investigate the value of T1WI signal intensity in the diagnosis of neonatal acute bilirubin eneephalopa- thy. Methods： 59 jaundice skin neonatal patients were divided into 4 groups. T1 WI, T2WI signal intensity of the bilateral glo bus pallidus in MRI images were measured and compared. Results： ① Naked eye observation： T1 WI signal of bilateral globus pallidus were higher in 6 patients of group IV , the T2 WI signal intensity were not significantly different. ②There were no sta- tistically significant difference between left and right g!obus pallidus T1WI signal intensity（ P P〉0.05）. The bilateral globus pallidus T1 WI signal intensity in group Ⅳ were significantly higher than the other groups （ P 〈0.05）. The bilateral globus pallidus T1WI signal intensity in group Ⅲ were significantly higher than group I and group It （ P 〈0.05）. There were no sig- nificant difference between T1WI signal intensity in group Ⅰ and group Ⅱ. No significant difference of T2 WI signal intensity, eADC,ADC value existed in all groups（ P〉0.05）. Conclusions： The symmetrical increases of the globus pallidus T1WI signal is an important feature of neonatal acute bilirubin encephalopathy, and is closely related with the serum bilirubin level.