中药纠正克罗米酚促排卵致低雌激素状态的临床观察

目的 探讨中药益精活血促孕汤纠正克罗米酚致低雌激素反应的效果。方法 将排卵功能障碍性不孕患者，随机分为观察组60例，应用克罗米酚+益精活血促孕汤；对照组58例，口服克罗米酚+戊酸雌二醇。结果 两组治疗后宫颈松弛，黏液明显改善；Inskr评分>8分观察组为63．3％(38／60)，对照组为43．1％(25／58)，两组比较，差异有显著性(P<0．05)。观察组治疗后子宫内膜(0．98±0．19)cm，较对照组(0．85±0．21)cm明显增厚(P<0．01)；观察组受孕25例(41．7％)，对照组受孕14例(24．1％)，受孕率明显提高(P<0．05)。结论 中药益精活血促孕汤能明显纠正克罗米酚低雌激素反应并提高受孕率。

Clinical Observation on Effect of Chinese Herbs in Adjusting Hypoestrogenemia Status by Clomiphene to Promote Ovulation

OBJECTIVE: To explore the effect of Yijing Huoxue Cuyun Decoction (YHCD) in adjusting hypoestrogenemic response induced by clomiphene. METHODS: Infertile patients caused by ovulation disturbance were randomly divided into 2 groups. The 60 patients in the observed group were treated with clomiphine plus YHCD, and the 58 patients in the control group were given clomiphine plus estradiol valerate. RESULTS: By scoring on the cervical relaxation and improvement of cervical mucus, 38 patients (63.3%) in the observed group had Insler score of more than 8 points, while that in the control group was only 25 (43.1%), comparison between the two groups showed significant difference (P < 0.05). The endometrium thickening in the observed group was 0.98 +/- 0.19 cm, significantly different to that in the control group (0.85 +/- 0.21 cm, P < 0.01). Twenty-five patients in the observed group (41.7%), and fourteen patients in the control group (24.1%), respectively got pregnancy, the pregnant rate in the former was obviously higher than that in the latter (P < 0.05). CONCLUSION: YHCD can ameliorate hypoestrinemia induced by clomiphene and increase the pregnant rate in patients.