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| RT-Q医用生物膜的止血及生物相容性研究 | |
| 引用本文： | 陈重华,程薇波,尹宗宁,田娟,陈国经. RT-Q医用生物膜的止血及生物相容性研究[J]. 中国临床药理学与治疗学, 2006, 11(12): 1345-1349 |
| 作者姓名： | 陈重华 程薇波 尹宗宁 田娟 陈国经 |
| 作者单位： | 1. 四川大学华西药学院药理教研室 2. 公共卫生学院毒理研究室,成都,610041,四川 3. 成都博联医疗信息产业有限责任公司,成都,610041,四川 |
| 基金项目： | 国家高技术研究发展计划(863计划) |
| 摘 要： | 目的：研究RT-Q医用生物膜（以下简称RT-Q膜）的术中局部止血作用及其生物相容性。方法：通过比较RT-Q膜、瞬康医用胶（以下简称瞬康胶）、附加剂、阴性对照对大鼠颈外静脉切口出血时间和出血量的影响，研究其术中止血效果；通过观察大鼠后肢肌肉切开用此膜后对伤口愈合、生物膜降解及周围组织是否有毒性影响等情况评价其生物相容性。结果：与阴性对照组、附加剂组比较，RT-Q膜组止血效果显著（P〈0．01），与瞬康医用胶组比较无统计学意义；RT-Q膜对伤口愈合既无促进也无延迟性影响，形成的膜于术后15d开始降解，3～4周完全吸收，对周围组织无毒性影响。结论：RT-Q医用生物膜的局部止血效果显著、且具有生物相容性。 |
| 关 键 词： | RT-Q膜 局部止血 生物相容性 |
| 文章编号： | 1009-2501(2006)12-1345-05 |
| 收稿时间： | 2006-05-30 |
| 修稿时间： | 2006-07-28 |
Study of hemostatic effect and biocompatibility of RT-Q-remedial biomembrane |
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| CHEN Zhong-hua,CHENG Wei-bo,YIN Zong-ning,TIAN Juan,CHEN Guo-jing. Study of hemostatic effect and biocompatibility of RT-Q-remedial biomembrane[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(12): 1345-1349 | |
| Authors: | CHEN Zhong-hua CHENG Wei-bo YIN Zong-ning TIAN Juan CHEN Guo-jing |
| Affiliation: | 1.West China School of Pharmacy, 2.Public Health, Sichnan University, Chengdu 610041, Sichnan , China ; 3. Chengdu Bolian Medical Information Industry Co. Ltd, Chengdu 610041, Sichnan, China |
| Abstract: | AIM: To investigate the hemostatic effect and biocompatibility of RT-Q-remedial biomembrane. METHODS: There were control, excipient, Shunkang and RT-Q group in topical bleeding experiment and control, excipient, and RT-Q group in topical biocompatibility experiment, in order to study the hemostatic effect on jugular vein of rat, and to observe the biodegradability and histocompatibility of RT-Q in muscle of rat legs. RESULTS: The hemostatic effect is significant compared with control group and excipient group (P< 0.01 ), but there is no significant difference compared with Shunkang group (P> 0.05 ). The biological evaluation for the biocompatibility is excellent. CONCLUSION: The significant hemostatic effect and good biocompatibility have been proved in topical bleeding of RT-Q. |
| Keywords: | RT-Q-biomembrane topical stanch biocompatibility |
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