| 补救的卵胞浆内单精子注射方法的评估 |
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| 引用本文： | 周平,CAO Yun-xia,丛林,ZHANG Zhi-guo,魏兆莲.补救的卵胞浆内单精子注射方法的评估[J].生殖医学杂志,2008,17(4):262-265. |
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| 作者姓名： | 周平 CAO Yun-xia 丛林 ZHANG Zhi-guo 魏兆莲 |
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| 作者单位： | 安徽医科大学第一附属医院妇产科生殖医学中心,合肥,230022 |
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| 摘 要： | 目的探讨对常规体外受精(IVF)后完全受精失败(TFF)的卵母细胞进行补救的卵胞浆内单精子注射(L-ICSI)方法的效果。方法自2002年1月至2007年2月对86对夫妇常规IVF后TFF的卵母细胞行L-ICSI,对取卵数目达到12个的原发不育,尤其是对原因不明和子宫内膜异位症不育的14对夫妇采用半数卵母细胞ICSI(Half-ICSI),并进行评估。结果L-ICSI与取卵日ICSI的受精率和分裂胚胎率差异非常显著(P<0.01),而且可移植胚胎数目减少,临床妊娠率极低,仅获得1.2%(1/86)的临床妊娠与分娩。31对L-ICSI的夫妇在本中心行第二次助孕治疗选择取卵日ICSI,获得41.9%(13/31)的妊娠率。Half-ICSI与L-ICSI比较,受精率、分裂胚胎率相似,但临床妊娠率(50%比1.2%)差异非常显著(P<0.01)。Half-ICSI受精率67.6%,临床妊娠率50%(5/10),与取卵日ICSI比较,差异无显著性(P>0.05)。结论L-ICSI作为补救措施作用甚小,建议对合适的人群采用Half-ICSI以避免TFF,提高临床妊娠率。
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| 关 键 词： | 卵胞浆内单精子注射 受精失败 半数卵胞浆内单精子注射 |
A study on late intracytoplasmic sperm injection after total conventional in-vitro fertilization failure |
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| ZHOU Ping,CAO Yun-xia,CONG Lin,ZHANG Zhi-guo,WEI Zhao-lian.A study on late intracytoplasmic sperm injection after total conventional in-vitro fertilization failure[J].Journal of Reproductive Medicine,2008,17(4):262-265. |
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| Authors: | ZHOU Ping CAO Yun-xia CONG Lin ZHANG Zhi-guo WEI Zhao-lian |
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| Institution: | ZHOU Ping,CAO Yun-xia,CONG Lin,ZHANG Zhi-guo,WEI Zhao-lian.Reproductive Medical Center,the First Affiliated Hospital,Anhui Medical University,Hefei 230022 |
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| Abstract: | Objective: The aim of this study was to evaluate the application of late intracytoplasmic sperm injection(L-ICSI) using total fertilization failured(TFF) oocytes by conventional in vitro fertilization(IVF).Methods: Between January 2002 and February 2007,TFF oocytes by conventional IVF in 86 couples were performed intracytoplasmic sperm injection.In the second trial,14 couples with unexplained infertility or endometriosis were treated by Half-ICSI in 2006.Results: The fertilization rate of L-ICSI oocytes(57.... |
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| Keywords: | Intracytoplasmic sperm injection Fertilization failure Half-ICSI |
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