消渴康对糖尿病肾病大鼠的治疗作用

目的:观察糖尿病肾病大鼠血糖、血脂、血清尿素氮、肌酐和糖化血红蛋白的变化以及消渴康的治疗作用。方法:采用腹腔一次性注射链尿佐菌素(STZ)、同时饲喂高脂饲料复制大鼠糖尿病肾病模型。将动物分为模型组、消渴康组和正常对照组,注射STZ4周后治疗组给予消渴康治疗。于注射STZ后8、12、16周取血测定空腹血糖、血脂、血清尿素氮和肌酐,第16周测定糖化血红蛋白。结果:注射STZ后8、12、16周模型组空腹血糖、血脂和尿素氮明显升高,12、16周血清肌酐和16周血液糖化血红蛋白明显高于正常组。消渴康治疗组与模型组同期比较以上指标有不同程度的减轻。结论:消渴康有良好的改善糖尿病高血糖、高血脂和肾功能损害的作用。

Influence of Xiaokekang on Renal Function in Diabetic Nephropathy Rats

Objective:To observe the changes of glycemia,urine protein,serum creatinine,blood urea nitrogen and glycosylated hemoglobin in diabetic nephropathy rats and treating effects of Xiaokekang.Methods: Streptozotocin(STZ) was abdominally administered and was feeded by high lipid diet to establish diabetic nephropathy model in rats.Animals were divided into three groups: model group,Xiaokekang treatment group and normal group.Changes in glycemia,serum lipids,serum creatinine,blood urea nitrogen were measured at the 8th,12th and 16th week after STZ injection.Glycosylated hemoglobin was measured at the 16th weeks after STZ injection.Results: Glycemia,serum lipids,serum creatinine were higher at the 8th,12th and 16th week compared with normal group.Serum creatinine was higher at the 12th and 16th week,and glycosylated hemoglobin was also highter than that of the normal group.Xiaokekang reduced these changes.Conclusion: Xiaokekang can reduce glycemia,serum lipids and protect renal function.