| 温度敏感性液体栓塞材料的体外实验研究 |
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| 引用本文： | 盛希忠,刘作勤,武乐斌,唐军,赵成如,孔令斌,王勤.温度敏感性液体栓塞材料的体外实验研究[J].山东医药,2005,45(11):1-3. |
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| 作者姓名： | 盛希忠 刘作勤 武乐斌 唐军 赵成如 孔令斌 王勤 |
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| 作者单位： | 山东大学医学院,山东济南,250012;山东省千佛山医院;山东省医学影像学研究所;山东省医疗器械研究所 |
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| 基金项目： | 国家863计划资助项目(No.002AA326100) |
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| 摘 要： | 目的合成一种新型温度敏感性液体栓塞材料，并探讨其栓塞脑动静脉畸形(AVM)的可能性。方法应用氮-异丙基丙烯酰胺和氮-正丙基丙烯酰胺合成共聚物，进行物理性质测定和体外AVM模型栓塞试验。结果共聚物具有低临界溶解温度(LCST)特性，具有水溶性和非黏附性等特点，能成功栓塞体外AVM模型。结论该共聚物为一种脑AVM血管内栓塞治疗的新型液体栓塞材料，可进一步用于动物实验。
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| 关 键 词： | 温度敏感性 共聚物 动静脉畸形 栓塞 |
| 修稿时间： | 2005年1月12日 |
In vitro experimental study of a thermosensitive liquid embolic material |
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| ShengXizhong,Liu Zuoqin,Wu Lebin,et al.In vitro experimental study of a thermosensitive liquid embolic material[J].Shandong Medical Journal,2005,45(11):1-3. |
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| Authors: | ShengXizhong Liu Zuoqin Wu Lebin |
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| Abstract: | Objective To synthesize a new thermosensitive liquid embolic material and investigate its embolic feasibility in cerebral arteriovenous malformations (AVM). Methods The copolymer was synthesized with N-isopropylacrylamide(NIPAM)and N-n-propylacrylamide(NNPAM)and its properties were analyzed. The arteriovenous malformation(AVM)models in vitro were embolized with the copolymer. Results The copolymer has unique thermal behavior of lower critical soluble temperature(LCST),it is soluble in water and nonadhesive and could embolize the AVM models in vitro successfully. Conclusion The copolymer is a new liquid embolic material for endovascular embolic treatment of AVM and may remain to be confirmed in further animal experiments. |
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| Keywords: | Thermosensitive Copolymer Arteriovenous malformation Embolization |
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