Alterations of atrial electrophysiology related to hemodialysis session: insights from a multiscale computer model |
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Authors: | Krueger Martin Wolfgang Severi Stefano Rhode Kawal Genovesi Simonetta Weber Frank Michael Vincenti Antonio Fabbrini Paolo Seemann Gunnar Razavi Reza Dössel Olaf |
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Affiliation: | a Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germanyb Biomedical Engineering Laboratory- DEIS- University of Bologna, Cesena, Italyc Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdomd Department of Clinical Medicine and Prevention, University of Milano Bicocca, Monza, Italye Nephrology Unit, San Gerardo Hospital, Monza, Italyf Electrophisiology and Cardiac Pacing Unit, San Gerardo Hospital, Monza, Italy |
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Abstract: | BackgroundThe prevalence of atrial fibrillation is increased in patients with end-stage renal disease. Previous studies suggested that extracellular electrolyte alterations caused by hemodialysis (HD) therapy could be proarrhythmic.MethodsMultiscale models were used for a consequent analysis of the effects of extracellular ion concentration changes on atrial electrophysiology. Simulations were based on measured electrolyte concentrations from patients with end-stage renal disease.ResultsSimulated conduction velocity and effective refractory period are decreased at the end of an HD session, with potassium having the strongest influence. P-wave is prolonged in patients undergoing HD therapy in the simulation as in measurements.ConclusionsElectrolyte concentration alterations impact atrial electrophysiology from the action potential level to the P-wave and can be proarrhythmic, especially because of induced hypokalemia. Analysis of blood electrolytes enables patient-specific electrophysiology modeling. We are providing a tool to investigate atrial arrhythmias associated with HD therapy, which, in the future, can be used to prevent such complications. |
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Keywords: | Hemodialysis Atrial electrophysiology Multiscale cardiac modeling Patient-specific modeling P-wave |
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