白细胞介素-11雾化吸入治疗鼻咽癌同期放化疗导致口腔黏膜炎的疗效观察

目的：探讨白细胞介素-11（IL-11）雾化吸入治疗鼻咽癌同期放化疗导致口腔黏膜炎的临床疗效，为鼻咽癌同期放化疗导致口腔黏膜炎的治疗提供新方法。方法选取2010年4月～2013年6月间于我院肿瘤科住院治疗的初诊为鼻咽癌的患者84例，于放疗后2周即药物雾化吸入前，及放疗第3～7周观察口腔黏膜反应变化情况；于放疗结束后1周，观察口腔黏膜反应愈合情况，对比分析IL-11雾化吸入对鼻咽癌同期放化疗导致口腔黏膜炎的治疗效果。结果两组患者放疗后第2周均出现口腔黏膜反应，但观察组患者的口腔黏膜反应分级与对照组相比无显著变化，但随着放射治疗的持续以及放射剂量的增加，观察组患者的口腔黏膜反应分级以Ⅰ～Ⅱ度黏膜反应为主，而对照组患者的口腔黏膜反应分级以Ⅱ～Ⅲ度黏膜反应为主，两组患者组间比较发现，观察组患者的口腔黏膜反应程度较对照组显著增加（P＜0.05）；放疗结束1周后，观察组对于口腔黏膜炎治疗的总有效率为90.5%，与对照组相比显著升高（x2=27.064，P=0.000）。结论 IL-11雾化吸入能够有效减轻鼻咽癌同期放化疗导致口腔黏膜反应的程度，对于口腔黏膜炎的治疗具有促进作用。

Efficacy of interleukin-11 inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma

Objective To investigate the clinical efficacy of interleukin-11（IL-11） inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma and to provide a new method for the treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma. Methods 84 patients were selected in the oncology of our hospital during April 2010 to June 2013, which were diagnosed with newly nasopharyngeal cancer. The changes of oral mucositis were observed before the drug inhalation and 3-7 weeks after radiotherapy, and the healing of oral mucositis were also observed one week after the end of radiotherapy. And then the clinical efficacies of interleukin-11（IL-11） inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma were analyzed comparatively. Results In the first two weeks, the patients of both two groups existed oral mucositis after radiotherapy, but compared with the control group, oral mucositis classification in the observation group had no change significantly, but with the continued increase in radiation dose and radiation therapy, the degree of the patients in the observation group were mainly grade Ⅰ - Ⅱdegree, and those in the control group were mainly Ⅱ - Ⅲ degree. Between two groups of patients found the oral mucosa of patients in the observation group compared with the extent of reaction the control group was significantly increased（P 〈 0.05）; 1 week after the end of radiotherapy, the effective rate was 90.5% in the observation group to the total oral mucositis treatment, compared with the control group was significantly higher（x2=27.064,P=0.000）. Conclusion IL-11 inhalation can effectively reduce the degree of oral mucositis caused by nasopharyngeal concurrent chemo-radiotherapy, and has a facilitating role for the treatment of oral mucositis.