血清CA125变化对判断卵巢癌疗效的价值探讨

目的探讨血清CA125值的变化对判断卵巢癌疗效分析。方法选取我院从2012年6月～2013年6月门诊收治的78例卵巢癌患者做为研究对象。按照人院顺序随机分为治疗组与对照组，每组39例。治疗组患者应用腹腔热灌注化疗（IPCH）方法化疗；对照组患者手术中使用热灌注疗法化疗。对比两组患者的临床治疗效果及治疗前后患者血清CA125值变化。结果治疗组患者的治疗总有效率显著高于对照组患者，差异具统计学意义（P〈0．05）。治疗组患者化疗后血清CA125值的变化显著优于对照组，差异具统计学意义（P〈0．05）。结论通过监测卵巢癌患者血清CA125值的变化，对于化疗方法及药物的临床治疗效果评价具有指导意义。

Discussion on the value of changes of serum CA125 in the prediction of curative effects of ovarian cancer

Objective To explore the changes of serum CA125 in the prediction of curative effects of ovarian cancer. Methods 78 patients with ovarian cancer who were admitted to our hospital from June 2012 to June 2013 were selected as subjects, and randomly assigned to treatment group and control group based on admission order, with 39 patients in each group. The treatment group received IPCH, while the control group received perfusion chemotherapy during operations. Clinical curative effects and changes of serum CA125 before and after treatment were compared between the two groups. Results Total effective rate in the treatment group was significantly higher than that in the control group and the difference was statistically significant（P 〈 0.05）. The changes of serum CA125 after the chemotherapy in the treatment group were significantly better than those in the control group, and the differences were statistically significant（P 〈 0.05）. Conclusion Monitoring the changes of serum CA 125 for patients with ovarian cancer is of guiding significance for the evaluation of clinical effects of chemotherapy methods and relevant medication.