慢性尿酸性肾病致肾功能损害患者的临床诊治研究

目的：探讨慢性尿酸性肾病致肾功能损害患者的临床诊治方法。方法选取本院2011年10月～2013年10月诊治的慢性尿酸性肾病致肾功能损害患者83例，根据治疗方案分为两组，41例患者实施常规治疗为对照组，42例患者加用别嘌呤醇为观察组，疗程8周，比较两组患者相关临床指标的改变情况、临床疗效、不良反应情况。结果治疗后，对照组患者血尿酸显著下降，而尿pH值显著升高。观察组患者血尿酸、血肌酐、尿素氮、24h尿蛋白均显著下降，而肾小球滤过率、尿pH值均显著升高。观察组患者血尿酸、血肌酐、尿素氮、24h尿蛋白均明显低于对照组，观察组患者肾小球滤过率、总有效率均明显高于对照组，差异均有统计学意义（P＜0.05）。结论别嘌呤醇是治疗慢性尿酸性肾病致肾功能损害的有效药物，可明显改善患者的临床指标，提高治愈率，引发的不良反应少，具有较高的安全性，值得临床推广使用。

Clinical research on diagnosis and treatment of patients with renal function damage induced by chronic uric acid nephropathy

Objective To investigate the diagnosis and treatment methods of patients with renal function damage induced by chronic uric acid nephropathy. Methods 83 patients with renal function damage induced by chronic uric acid nephropathy were selected in hospital from October 2011 to October 2013.According to treatment,the patients were divided into two groups.41 patients received routine treatment as control group. 41 patients combined with allopurinol as observation group.Course of treatment was 8 weeks.Changes of relevant clinical indexes,clinical efficacy,adverse reactions were compared between two groups. Results After treatment, blood uric acid significantly decreased while urine pH significantly increased in control group. Blood uric acid,blood creatinine,urea nitrogen,24h urinary protein significantly decreased while glomerular filtration rate,urine pH significantly increased in observation group. Blood uric acid,blood creatinine,urea nitrogen,24h urinary protein in observation group were significantly lower than control group. Glomerular filtration rate and total effective rate in observation group were significantly higher than control group. Differences were statistically significant（P 〈 0.05）. Conclusion Allopurinol is an effective drug in treatment of renal function damage induced by chronic uric acid nephropathy,which can significantly improve clinical indexes and improve cure rate. Allopurinol can cause less adverse reactions,which has high security and worth of clinical use.