复方丹参滴丸对不稳定型心绞痛患者血小板活化功能的影响

目的探讨复方丹参滴丸治疗冠心病心绞痛的临床疗效及其对血小板活化功能的影响。方法选择本院2012年8月～2013年10月收治的不稳定型心绞痛患者90例，随机分为两组，两组均给予抗凝、降脂、扩血管治疗，研究组患者在常规治疗的基础上给予复方丹参滴丸治疗。观察两组治疗效果，治疗前后采集静脉血，检测CD62p、GMP-140水平，评估患者治疗前后患者血小板活化功能的变化情况。结果两组心绞痛治疗总有效率比较，研究组明显高于对照组，差异有统计学意义（P〈0．05）。两组治疗前CD62p、GMP-140差异均无统计学意义，治疗后两组CD62p、GMP-140均较治疗前降低，但研究组CD62p、GMP-140均明显低于对照组（P〈0．05）。结论复方丹参滴丸辅助治疗不稳定型心绞痛疗效较好，并且可以有效抑制血小板活化功能的异常，值得应用。

The influce of compound danshen dripping pills on platelet activation function in patients with unstable angina

Objective To evaluate the clinical efficacy of compound danshen dripping pills （ CSDP ） in treatment of unstable angina and its influce on platelet activation functions. Methods 90 patients with unstable angina in our hospital from August 2012 to October 2013 were randomly divided into two groups, two groups were all given anticoagulation,lipid -lowering,vasodilator dilation therapy,the patients of study group were given CSDP based on the conventional therapy.Therapeutic effects of two groups were observed, serum samples of patients were collected before and after treatment,CD62p,GMP-140 levels before and after treatment were tested to assess platelet activation functions. Results The total effective of the study group was significantly higher than control group,the difference was significant （P 〈 0.05）.Before treatment CD62p, GMP-140 between the two groups were no significantly different, after treatment GMP-140 CD62p all reduced, but the CD62p,GMP-140 of study group were significantly lower than the control group（P 〈 0.05） . Conclusion The effect of CSDP assisted in treatment of unstable angina pectoris is better,and can effectively inhibit the abnormal platelet activation, worthy of applications.