血浆D-二聚体与纤维蛋白原在下肢深静脉血栓中的诊断价值

目的：探讨D-二聚体（DD）和纤维蛋白原（FIB）在下肢深静脉血栓形成（DVT）诊断中的临床意义。方法对52例疑似DVT患者进行血浆DD和FIB检测，并计算D-二聚体/纤维蛋白原比值（D/F值），根据彩色多普勒超声检查结果明确诊断，同时选取健康体检者50例作为对照组。结果 DVT组血浆DD、FIB及D/F值均明显高于健康对照组，差异有统计学意义（P＜0.01）；DVT组与非DVT组比较，DVT组DD、FIB和D/F值明显高于非DVT组具有显著性差异（P＜0.01），D/F值、DD、FIB对诊断DVT的敏感度分别为98%、94%、85%，D/F值在诊断DVT中较单独应用DD或FIB有较高的敏感度。结论检测血浆DD、FIB及D/F比值可提高DVT临床诊断的特异性，对下肢深静脉血栓的早期诊断具有重要的临床意义。

The diagnostic value of plasma D-dimer and fibrinogen in lower limb deep venous thrombosis

Objective To explore the diagnostic value of plasma D-dimer and fibrinogen in lower limb deep venous thrombosis（DVT）. Methods 52 patients with suspected DVT were selected to be carried out the test on plasma DD and FIB ：and calculated d-dimer/fibrinogen ratio（D/F values）.According to color doppler ultrasonography examination results determined diagnosis. At the same time： 50 healthy subjects were in the control group. Results The plasma DD and FIB levels and D/F values in DVT group were significantly higher than that of the healthy control group：the differences were statistically significant（P 〈 0.01）. The plasma DD and FIB levels and D/F values in DVT group were higher than those in non-DVT group：and there was significant difference（P〈0.01）. The sensitivity of D/F values：DD and FIB were respectively 98%,94%,85%.The D/F values had higher sensitivity than the DD or FIB increased in the diagnosis of DVT. Conclusion The testing of plasma DD：FIB and D/F values could improve the specificity in DVT diagnosis and had important clinical significance on the early diagnosis of DVT.