The Effect of Ellagic Acid on Coagulation in Vivo |
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| Authors: | GIROLAMI, ANTONIO AGOSTINO, DOMENICO CLIFFTON, EUGENE E. |
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| Affiliation: | 1 Clotting Mechanisms Section of the Division of Experimental Surgery andPhysiology, Sloan-Kettering Institute for Cancer Research, and Cornell University Medical College, New York, N. Y.
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| Abstract: | Ellagic acid shortens the silicone and glass clotting times of the blood ofdogs, cats, rabbits and rats. The silicone clotting time is reduced so as tomake it almost equal to the normal glass clotting time for 5 to 30 minutesafter the injection of the agent. There is occasional acceleration of thromboplastin generation in dogs. No other clotting factors were altered significantlyin our experiments.There were no obvious toxic effects of ellagic acid, and it appears to decrease bleeding in normal animals. Submitted on February 15, 1965 Accepted on May 8, 1965 |
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