当归腹宁滴丸微生物限度检查法的建立

目的:建立当归腹宁滴丸微生物限度检查法。方法:测定当归腹宁滴丸对5种验证菌株的回收率,并对控制菌的检查法进行验证。结果:当归腹宁滴丸对金黄色葡萄球菌、枯草芽孢杆菌有较强的抑制作用,对大肠埃希菌、白色念珠菌、黑曲霉菌无抑制作用。结论:采用薄膜过滤法可消除当归腹宁滴丸在试验条件下的抑菌作用,并进行菌数计数检验;采用常规法即可进行控制菌检查。

Establishment of Microbial Limit Test for Danggui Funing Drop Pills

OBJECTIVE： To establish the Microbial limit test（MLT） for Danggui funing drop pills.METHODS： The recovery rates of 5 tested strains treated by Danggui funing drop pills were detected and the MLT method for the control bacteria was validated.RESULTS： Danggui funing drop pills exhibited strong inhibitory effect on staphylococcus aureus and bacillus subtilis,but showed no effect on escheriehia coli, candida albicans and aspergillus niger. CONCLUSION： By membrane-filter procedure, the antibacterial effect of Danggui funing drop pills can be eliminated and the bacterial count can be conducted; however, by routine method, the test of control bacteria is feasible.