常规疗法加用氟哌噻吨美利曲辛治疗功能性消化不良的疗效观察

目的:观察常规疗法加用氟哌噻吨美利曲辛治疗功能性消化不良(FD)的疗效。方法:320例FD患者按临床特点分为动力障碍型(A型)、溃疡型(B型)、非特异型(C型)各120、100、100例。各型随机分为氟哌噻吨美利曲辛+常规疗法(合用组)和常规疗法(常规组),疗程均为4周,胃肠症状评分法(GSRS)观察疗效并计算总有效率。结果:A、B、C型FD的合用组和常规组治疗后的GSRS评分分别为1.53±1.68和3.10±1.78、2.02±1.63和3.48±1.80、3.46±2.95和5.18±3.21(P<0.01),总有效率分别为91.4%和69.4%、86.0%和68.0%、90.2%和77.6%(P<0.01)。结论:常规疗法加用氟哌噻吨美利曲辛能显著改善FD的临床症状,提高FD治疗的总有效率。

Observation of Therapeutic Effects of the Conventional Therapy plus Melitracen and Flupentixol in the Treatment of Functional Dyspepsia

OBJECTIVE： To observe the therapeutic effects of the conventional therapy plus Melitracen and Flupentixol in the treatment of functional dyspepsia （FD）. METHODS： 320 FD cases were divided into gastrointestinal dyskinesis type （Type A, n = 120 cases）, ulceration type （Type B, n = 100 cases）, and non-specific type （Type C, n = 100 cases） based on their clinical symptoms. Patients of different clinical types were randomly assigned to receive conventional therapy alone or in combination with Melitracen and Flupentixol for 4 weeks. The curative effects were observed using gastrointestinal symptom rating scale （GSRS） and the total effective rate were computed. RESULTS： After treatment, the GSRS score of 3 different clinical types of FD in the combination therapy group versus the conventional therapy alone were 1.53 ± 1.68 vs. 3.10± 1.78, 2.02 ± 1.63 vs. 3.48± 1.80 and 3.46± 2.95 vs. 5.18± 3.21 respectively （P〈0.01）, the total effective rates were 91.4% vs. 69.4%, 86.0% vs. 68.0% and 90.2% vs. 77.6% respectively （P〈0.01）. CONCLUSION： Conventional therapy plus Melitracen and Flupentixol can improve the symptoms and the total effective rate of FD.