注射用伏立康唑临床合理使用评价标准的建立

目的:建立注射用伏立康唑临床药物利用评价标准,对该药的药物利用情况进行回顾性评价,为合理应用伏立康唑提供依据。方法:以伏立康唑的应用指南作参考,在查阅相关文献基础上制定伏立康唑药物利用评价细则,并对我院2014年6月1日至2014年12月31日62例出院病历进行回顾性评价。结果:研究发现临床应用伏立康唑时在给药途径、溶媒选用和配制方面符合标准率均为100%,但在用药指征、配伍禁忌、病原学检查、滴注时间、用药疗程和用药监护等方面存在不合理现象,而且我院的医院信息系统(hospital information system,HIS)特殊级抗菌药物管理系统存在操作漏洞。结论:伏立康唑药物利用评价方法可用于该药的药物利用评价,评价结果说明我院注射用伏立康唑的使用还存在普遍不合理应用现象,需加强合理用药宣传和监管,我院的电子监管系统仍然有操作漏洞,需要进一步完善。

Evaluation criteria establishment on reasonable application for IV admin-istration of voriconazole

Objective:To establish the evaluation standard of reasonable application for intravenous injection ( IV) administra-tion of voriconazole. According the evaluation criteria,retrospectively evaluate the use of IV administration of voriconazole to provide the theoretic foundation for rational application for IV administration of voriconazole. Methods: According to voriconazole guideline and relative references,the specific evaluation criteria on reasonable application for IV administration of voriconazole were established. 62 cases from Jun. 1,2014 to Dec. 31,2014 were retrospectively evaluated by the established evaluation criteria. Results: The results showed that the Conform-to-the-standard-rate of the routes of administration,solvent selections and preparation methods were all 100%. However,unreasonable drug-use existed in aspects of indication,incompatibility,etiological examination,infusion time,course of treat-ment,drug monitoring. In addition,the special class antibacterial drug management system of HIS management system in our hospital had a few operation flaws. Conclusion: The evaluation criteria for IV administration of voriconazole can be applied to evaluate the drug-use. Unreasonable drug-use exists in this hospital. Irrational IV administration of voriconazole are fairly common problems in this hospital,which means publicizing and supervising should be tightened,and the electronic information system needs to be perfected.