| 荭草苷对缺氧模型小鼠的抗缺氧作用研究 |
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| 引用本文： | 付晓春,李少鹏,邱蔚芬,王希.荭草苷对缺氧模型小鼠的抗缺氧作用研究[J].中国药房,2006,17(9):654-656. |
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| 作者姓名： | 付晓春 李少鹏 邱蔚芬 王希 |
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| 作者单位： | 1. 广东化工制药职业技术学院,广州市,510520;广东省中药研究所,广州市,510520
2. 广东东莞市人民医院,东莞市,517000 |
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| 基金项目： | 广东省中医药管理局科研项目 |
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| 摘 要： | 目的:研究荭草苷对缺氧模型小鼠的抗缺氧作用。方法:通过常压耐缺氧、亚硝酸钠中毒、氰化钾中毒、利多卡因中毒、夹闭气管及断头等建立小鼠缺氧模型,于造模前20min给予相应药物,观察药物的抗缺氧作用。结果:与生理盐水空白对照组比较,荭草苷可明显延长模型小鼠在常压缺氧、亚硝酸钠中毒、氰化钾中毒、利多卡因中毒时的存活时间,延长夹闭气管后的心电图消失时间及断头后的喘气时间。结论:荭草苷对缺氧模型小鼠具有抗缺氧作用。
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| 关 键 词： | 荭草苷 小鼠 缺氧模型 抗缺氧作用 |
| 文章编号： | 1001-0408(2006)09-0654-03 |
| 收稿时间： | 09 28 2005 12:00AM |
| 修稿时间： | 12 23 2005 12:00AM |
Antihypoxic Effect of Orientoside on Hypoxia Model Mice |
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| FU Xiaochun,LI Shaopeng,QIU Weifen,WANG Xi.Antihypoxic Effect of Orientoside on Hypoxia Model Mice[J].China Pharmacy,2006,17(9):654-656. |
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| Authors: | FU Xiaochun LI Shaopeng QIU Weifen WANG Xi |
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| Abstract: | OBJECTIVE:To evaluate the antihypoxic effect of orientoside on hypoxia model rats.METHODS:The hy-poxia rats model was established through normobaric hypoxia,poisoning with sodium nitrite,potassium cyanide and lidocaine,trachea occlusion,decapitation,etc.20minutes prior to the modeling,the rats were administered with the corresponding drugs with the anti-hypoxic effects observed.RESULTS:As compared with placebo group,the survival time of rats under nor-mobaric hypoxia,poisoned by sodium nitrite,potassium cyanide and lidocaine,and the electrocardiograph extinction time after trachea occlusion and the gasping time of mice after decapitation were all significantly prolonged by orientoside.CONCLU-SION:Orientoside has antihypoxic effect on hypoxia model rats. |
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| Keywords: | Orientoside Mouse Hypoxia model Anti-hypoxie effect |
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