E-钙黏素和β-连环素在子宫内膜癌组织中表达状况的研究

目的：探讨E-钙黏素和β-连环素的表达状况与子宫内膜癌的关系。方法：采用免疫组织化学SP法检测38例正常子宫内膜、36例不典型增生子宫内膜组织和65例子宫内膜癌中E-钙黏素和β-连环素的表达。结果：E-钙黏素和β-连环素在正常子宫内膜、不典型增生子宫内膜和子宫内膜癌组织的异常表达率逐渐增高（P＜0.05）。E-钙黏素的表达与子宫内膜癌的组织学分级、肌层浸润深度、手术-病理分期有关。β-连环素的表达与子宫内膜癌的组织学分级、手术-病理分期、淋巴结转移有关。结论：E-钙黏素和β-连环素在子宫内膜癌的发生发展中起重要作用，分析E-钙黏素、β-连环素在子宫内膜癌中的表达有助于评价肿瘤的恶性程度和转移能力，判断肿瘤的预后。

Expression of E-cadherin and Beta-catenin in Endometrial Carcinoma

Objective： To detect the relationship between expression of E-cadherin and beta-catenin with endometrial carcinoma. Methods： A total of 65 specimens of endometrial carcinoma，38 normal endometrial tissues and 36 atypical hyperplasia endometrium tissues were evaluated by immunohistochemical technique with monocolonal antibodies against E-cadherin and beta-catenin. Results：The aberrant expression rates of E-cadherin and beta-catenin increased obviously from normal endometrial tissues，atypical hyperplasia endometrium tissues to endometrial carcinoma tissues（P<0.05）. Expression of E-cadherin was positively correlated with tumor grade，mymetrial invasion，surgical stage and lymphnode matastasis（P<0.05）. Expression of beta-catenin was also significantly correlated with tumor grade，surgical stage and lymphnode matastasis（P<0.05）. Conclusions： The aberrant expression of E-cadherin and beta-catenin was positively related to oncogenesis，invasion，metastasis and prognosis of endomentrial carcinoma. It should be considered to a certain extent as an index of malignant degree and prognosis of endomentrial carcinoma.