Sedative, vasorelaxant, and cytotoxic effects of convolvulin from Ipomoea tyrianthina |
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Authors: | León-Rivera Ismael Herrera-Ruiz Maribel Estrada-Soto Samuel Gutiérrez María del Carmen Martínez-Duncker Iván Navarrete-Vázquez Gabriel Rios María Yolanda Aguilar Berenice Castillo-España Patricia Aguirre-Moreno Alma |
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Affiliation: | a Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico b Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico c Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico d Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico e Centro de Investigación Biomédica del Sur, IMSS, Argentina 1, Col. Centro, 62790 Xochitepec, Morelos, Mexico |
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Abstract: | Aim of the studyIpomoea tyrianthina has been used in Mexican traditional medicine as a mild purgative, for the treatment of nervous disorders, and against tumors. In this study, the effect of convolvulin (an ether-insoluble resin glycoside) from the root of Ipomoea tyrianthina on: Central Nervous System; as spasmolytic and vasodilator; cytotoxic against cancer cell lines is evaluated.Materials and methodsConvolvulin isolated from the root of Ipomoea tyrianthina (IT-EM) was tested on pentylentetrazole induced seizures, pentobarbital-induced hypnosis, release of GABA and glutamic acid, isolated rat aorta and ileum rings, and against Caco-2 and KB cell lines.ResultsIT-EM increased the hypnotic effect induced by pentobarbital and the release of GABA in brain cortex of mice, but did not protect mice against pentylenetetrazole-induced convulsions. IT-EM produced a significant vasodilator effect in concentration- and endothelium-dependent manners on isolated rat aorta, but did not inhibit significantly contractions on rat ileum, colon, and jejune rings. IT-EM showed cytotoxic activity against nasopharyngeal carcinoma KB cell line.ConclusionsConvolvulin (IT-EM) from Ipomoea tyrianthina has sedative effect, vasorelaxant effect in concentration- and endothelium-dependent manners, and cytotoxic activity against nasopharyngeal carcinoma KB cell line. |
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Keywords: | AOA, amino-oxyacetic acid ANOVA, analysis of variance CNS, central nervous system DZP, diazepam GABA, gamma amino butyric acid HPLC, high performance liquid chromatography IT-EM, ether-insoluble resin glycoside from Ipomoea tytrianthina NA, noradrenaline PTZ, pentylenetetrazole TW 2.5%, 2.5% Tween 20 solution |
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