The latex obtained from Hancornia speciosa Gomes possesses anti-inflammatory activity |
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Authors: | Marinho Diogo Guimarães Alviano Daniela Sales Matheus Maria Eline Alviano Celuta Sales Fernandes Patricia Dias |
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Institution: | a Laboratório de Farmacologia da Inflamação e do Óxido Nítrico, Programa de Desenvolvimento de Fármacos, ICB, Universidade Federal do Rio de Janeiro, Brazil b Instituto de Microbiologia, Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, Brazil |
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Abstract: | Aim of the studyHancornia speciosa Gomes (Apocynaceae) is a tree that is widely distributed throughout Brazil. Its latex is collected and used extensively to treat acne, warts, diseases related to bursitis, and inflammation. In this work, we describe the anti-inflammatory effects of the latex.Materials and methodsThe latex from Hancornia speciosa (0.06-1.3 mg/kg, p.o.) and the reference drug acetylsalicylic acid (ASA, 200 mg/kg, p.o.) were evaluated in analgesia (formalin-induced licking, acetic acid-induced contortions, and hot plate) and inflammation models (formalin-induced licking, paw oedema, and subcutaneous air pouch, with measurement of cell migration, exudate volume, protein extravasations, nitric oxide, prostaglandin E2, TNF-α, and IL-6, and expression of the enzymes inducible nitric oxide synthase and cyclooxygenase 2).ResultsThe latex from Hancornia speciosa significantly inhibited the number of writhings and the time that the animal spent licking the formalin-injected paw (second phase). Doses of 0.1-1.3 mg/kg latex reduced carrageenan-induced rat paw oedema. However, only the highest doses (0.6 and/or 1.3 mg/kg) reduced the oedema induced by bradykinin, histamine, and serotonin. The latex also inhibited inflammation induced by subcutaneous carrageenan injection, cell migration, exudate volume, protein extravasations, increased levels of inflammatory mediators (nitric oxide, prostaglandin E2, TNF-α, and IL-6) produced in the pouch, and increased expression of the enzymes nitric oxide synthase and cyclooxygenase 2.ConclusionsOur results indicate that the latex obtained from Hancornia speciosa demonstrates significant anti-inflammatory activity through the inhibition of nitric oxide, PGE2, and cytokine production, thus confirming the popular use of this plant as an anti-inflammatory agent. |
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Keywords: | Hancornia speciosa Latex Inflammation Anti-inflammatory activity |
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