Effect of interval between transcatheter hepatic arterial embolization and radiofrequency ablation on ablated lesion size in a swine model |
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Authors: | Cao Guang Nobuyuki Kawai Morio Sato Isao Takasaka Hiroki Minamiguchi Shinya Sahara Kouhei Nakata Tetsuo Sonomura Shintaro Shirai Ichiro Mori Renjie Yang |
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Institution: | Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan. |
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Abstract: | Purpose The aim of the study was to clarify the effect of the interval between transcatheter hepatic arterial embolization (TAE) with Lipiodol plus gelatin sponge particles and radiofrequency (RF) ablation on the extent of ablation. Materials and methods Eight healthy swine were divided into four groups: RF ablation (ablation only), RF ablation immediately after TAE (immediate ablation), RF ablation 3 days after TAE (3-day ablation), and RF ablation 6 days after TAE (6-day ablation). Five ablated lesions were created in each swine (10 per group). A 2-cm expandable LeVeen needle electrode was used for RF ablation. Ablated lesions are composed of an outer reddish zone and an inner whitish zone. Results The average longest length of the major, intermediate, and minor axes and the volume in the immediate ablation, 3-day ablation, and 6-day ablation groups were significant longer and greater (1.52 and 1.52, 1.46 and 1.50, and 1.37 and 1.35 times greater in the red zone and the whitish area, respectively) than those in the ablation-only group (P < 0.05/3). Accumulation of Lipiodol was still noted in the hepatic sinusoids in the 3-day and 6-day ablation groups. Conclusion RF ablation delayed to 6 days following TAE produced larger ablation volumes than did RF ablation alone. |
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