Low dosage of levomepromazine did not increase plasma concentrations of fluvoxamine |
| |
Authors: | Yoshimura R Ueda N Nakamura J |
| |
Institution: | Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan. yoshi621@med.uoeh-u.ac.jp |
| |
Abstract: | The cytochrome enzyme P450 2D6 (CYP2D6) is thought to play a role in the human metabolism of fluvoxamine. Levomepromazine is a potent inhibitor of CYP2D6. We coadministered a low dosage of levomepromazine and fluvoxamine in 15 patients and found that the low dosage of levomepromazine was effective in counteracting the fluvoxamine-induced insomnia and did not increase plasma fluvoxamine levels. These results suggest that the inhibition of CYP2D6 by levomepromazine has little effect on fluvoxamine metabolism. Therefore, a low dosage of levomepromazine, used as a hypnotic agent, appears to be effective and safe when coadministered with fluvoxamine. Since this was a pilot study without a placebo control, a double-blind placebo-controlled study is needed to confirm our preliminary findings. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|