Cost‐effectiveness of a lifestyle modification program in long‐term survivors of hemopoietic stem cell transplantation

To evaluate the cost‐effectiveness of a lifestyle modification program targeting long‐term survivors of hematological malignancy treated with hemopoietic stem cell transplantation, a multistate life table Markov model was used to calculate health outcomes for both the intervention and no intervention. Cost per health‐adjusted life year (HALY) saved was reported for four scenarios: all participants with/without standard weight regain, and participants who at baseline were overweight with/without standard weight regain. The program recruited 53 participants and was associated with reductions in body weight of 2.2 kg and BMI 0.8 units on intervention completion (12 months) at a cost of $1233/participant. These adipose reductions were sustained and remained significant at 24 months. The incremental cost‐effectiveness ratios varied from $118 418 per HALY to dominant, depending on the weight regain assumption. The program may be cost‐effective in transplant survivors, with the results most sensitive to the weight regain assumption and intervention cost.