Long‐term outcomes and transmission rates in hepatitis C virus‐positive donor to hepatitis C virus‐negative kidney transplant recipients: Analysis of United States national data |
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Authors: | Gaurav Gupta Le Kang Jonathan W. Yu Ashley J. Limkemann Victoria Garcia Dipankar Bandyopadhyay Dhiren Kumar Hasan Fattah Marlon Levy Adrian H. Cotterell Amit Sharma Chandra Bhati Trevor Reichman Anne L. King Richard Sterling |
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Affiliation: | 1. Division of Nephrology, Virginia Commonwealth University, Richmond, VA, USA;2. Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA;3. Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA;4. Section of Hepatology, Virginia Commonwealth University, Richmond, VA, USA |
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Abstract: | The use of kidneys from hepatitis C virus (HCV)‐positive (D+) deceased donors for HCV‐negative recipients (R?) might increase the donor pool. We analyzed the national Organ Procurement and Transplant Network (OPTN) registry from 1994 to 2014 to compare the outcomes of HCV D+/R? (n = 421) to propensity‐matched HCV‐negative donor (D?)/R? kidney transplants, as well as with waitlisted patients who never received a transplant, in a 1:5 ratio (n = 2105, per matched group). Both 5‐year graft survival (44% vs 66%; P < .001) and patient survival (57% vs 79%; P < .001) were inferior for D+/R? group compared to D?/R?. Nevertheless, 5‐year patient survival from the time of wait listing was superior for D+/R? when compared to waitlisted controls (68% vs 43%; P < .001). Of the 126 D+/R? with available post‐transplant HCV testing, HCV seroconversion was confirmed in 62 (49%), likely donor‐derived. Five‐year outcomes were similar between D+/R? that seroconverted vs D+/R? that did not (n = 64). Our analysis shows inferior outcomes for D+/R? patients although detailed data on pretransplant risk factors was not available. Limited data suggest that HCV transmission occurred in half of HCV D+/R? patients, although this might not have been the primary factor contributing to the poor observed outcomes. |
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Keywords: | donor‐derived transmission hepatitis C‐negative recipients hepatitis C‐positive donors kidney transplantation long‐term outcomes |
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