| vWF基因多态性与妊娠期高血压疾病症状的研究 |
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| 引用本文： | 陈颖,郑莹. vWF基因多态性与妊娠期高血压疾病症状的研究[J]. 中国妇幼保健, 2006, 21(15): 2142-2144 |
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| 作者姓名： | 陈颖 郑莹 |
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| 作者单位： | 长春市妇产科医院,130041 |
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| 摘 要： | 目的:探讨血管性假血友病因子(vWF)基因19内含子M spⅠ的多态性与妊娠期高血压疾病蛋白尿的发生及血压之间的关系。方法:采用聚合酶链反应-限制性内切酶片断长度多态性(PCR-RFLP)技术,检测70例妊娠期高血压疾病患者的vWF基因19内含子M spⅠ的多态性位点频率。结果:M-/M-基因型患者血压比M+/M+和M+/M-基因型两组患者血压低,而尿蛋白阳性率则更高。P<0.05。结论:vWF基因19内含子M spⅠ酶切位点多态性可能与妊娠期高血压病临床症状有关。
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| 关 键 词： | 血管性假血友病因子 多态现象(遗传学) 基因 妊娠期高血压疾病 |
| 文章编号： | 1001-4411（2006）15-2142-03 |
| 收稿时间： | 2006-06-26 |
| 修稿时间： | 2006-06-26 |
The Association of Von Willebrand Factor Gene With the Symptoms of Hypertensive Disorder Complicating Pregnancy |
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| CHEN Ying,ZHENG Ying. The Association of Von Willebrand Factor Gene With the Symptoms of Hypertensive Disorder Complicating Pregnancy[J]. Maternal and Child Health Care of China, 2006, 21(15): 2142-2144 |
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| Authors: | CHEN Ying ZHENG Ying |
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| Affiliation: | Obstetrics and Gynecology Hospital of Chanchun City, Changchun 130062, China |
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| Abstract: | Objective:In order to ascertain the relationship between von Willebrand factor gene MspI polymorphism in intron 19 and the symptoms of hypertensive disorder complicating pregnancy among Chineses.Methods:Msp I polymorphism was studied by PCR and Msp I digestion in 70 cases with hypertensive disorder complicating pregnancy.Results:The blood pressure of M-/M-genotype is higher than M /M and M /M-genotypes and the frequencie of proteinuria is lower than another groups.Conclusion:MspI polymorphism in intron 19 in the von Willebrand factor gene may be associated with the hypertension and proteinuria of hypertensive disorder complicating pregnancy among Chinese. |
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| Keywords: | Von Willebrand factor Polymorphism Genes Hypertensive disorder complicating pregnancy |
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