| 牛黄解毒片的遗传毒性研究 |
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| 引用本文： | 董菊,唐萌,王妹. 牛黄解毒片的遗传毒性研究[J]. 癌变．畸变．突变, 2009, 21(6): 477-478,485 |
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| 作者姓名： | 董菊 唐萌 王妹 |
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| 作者单位： | 1. 南京中医药大学基础医学院预防医学教研室,江苏,南京 210046
2. 东南大学公共卫生学院,江苏 南京,210009 |
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| 基金项目： | 南京中医药大学青年科技基金资助项目 |
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| 摘 要： | 背景与目的：评价牛黄解毒片是否具有遗传毒性作用。材料与方法：采用Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验对牛黄解毒片进行遗传毒性检测。结果：Ames试验各剂量组回变菌落数均未超过溶剂对照组的2倍，3个剂量组的微核率和精子畸形率与溶剂对照组比较，差异均无统计学意义（P〉0．05）。结论：在本试验条件下，牛黄解毒片未见遗传毒性作用。
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| 关 键 词： | 雄黄 牛黄解毒片 遗传毒性 |
Genotoxicity of Bezoar Antidotal Tablets |
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| DONG Ju,TANG Meng,WANG Shu. Genotoxicity of Bezoar Antidotal Tablets[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2009, 21(6): 477-478,485 |
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| Authors: | DONG Ju TANG Meng WANG Shu |
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| Affiliation: | DONG Ju1,TANG Meng2,WANG Shu2(1.Institute of Basic Medical Science,Nanjing University of Traditional Chinese Medicine,Nanjing 210046,2.School of Public Health,Southeast University,Nanjing 210009,China) |
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| Abstract: | BACKGROUND AND AIM: To evaluate the genotoxicity of bezoar antidotal tablets.MATERIALS AND METHODS: The Ames test,the mouse micronucleus test and the mouse sperm abnormality test were used to evaluate the genotoxicities of bezoar antidotal tablet.RESULTS: In the Ames test,the number of revertants in all dose groups was less than twice that of solvent control group.In the mouse micronucleus test and sperm abnormality test,no significant differences were observed in the three dose groups compared with that of... |
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| Keywords: | reaglar bezoar antidotal tablet genotoxicity |
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