Effect of contraceptive steroids on arginine- stimulated glucagon and insulin secretion in women. II. Carbohydrate and lipid physiology in insulin-dependent diabetics. |
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Authors: | P Beck D M Arnett R N Alsever R P Eaton |
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Affiliation: | 1. Department of Medicine, University of Colorado School of Medicine, Denver, Colo., USA;2. Department of Medicine, the University of New Mexico School of Medicine, Albuquerque, N.M., USA |
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Abstract: | The effect of contraceptive steroids on aminogenic glucagon secretion was studied in six insulin-dependent diabetic women. After 2 wk treatment with combined mestranol (80 mug) plus norethindrone (1 mg) daily, the mean peak plasma glucagon response to arginine infusion was suppressed to one-fourth of control levels. This was associated with a small but significant decrease in mean basal plasma cholesterol concentrations. There were no changes in basal plasma triglyceride, free fatty acid, glucose, insulin, or alpha-amino nitrogen concentrations or in daily insulin requirements during mestranol plus norethindrone treatment. These results confirm previous reports of no consistent changes in the insulin requirements of insulin-dependent diabetic women using contraceptive steroids and suggest that these women may not experience dramatic changes in their lipid metabolism during contraceptive therapy. |
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Keywords: | Reprint requests should be addressed to Dr. Paul Beck University of Colorado School of Medicine 4200 East Ninth Avenue Denver Colo. 80220. |
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