l-Baclofen-sensitive GABAB binding sites in the medial vestibular nucleus localized by immunocytochemistry |
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Authors: | Gay R. Holstein Giorgio P. Martinelli Bernard Cohen |
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Abstract: | l-Baclofen-sensitive GABAB binding sites in the medial vestibular nucleus (MVN) were identified immunocytochemically and visualized ultrastructurally inl-baclofen-preinjected rats and monkeys, using a mouse monoclonal antibody with specificity for the p-chlorophenyl moiety of baclofen. Saline-preinjected animals showed no immunostain. In drug-injected animals, there was evidence for both pre- and postsynaptic GABAergic inhibition in MVN mediated by GABAB receptors. These neural elements could be utilized in control of velocity storage in the vestibulo-ocular reflex. |
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Keywords: | γ -Aminobutyric acid GABAB receptor Baclofen Vestibulo-ocular reflex Medial vestibular nucleus |
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