Effects of Zaizhang-I,a traditional chinese medicine,on immunologically mediated aplastic anemia in mice |
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| Authors: | Zhou Jian-feng He Mei-dong Li Ming-zheng Yang Wei Tang Jing-zhi Sheng Guanxi Zhu Hui-feng Shao Jin-fang Yang Jin |
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| Institution: | (1) Integrated traditional Chinese medicine and western medicine institution. Tongji hopital, Tongji Medical University, Wuhan;(2) Experimental Medical Research Center Immune Department of Tongji, Medical University, Wuhan;(3) Department of Hemotology, Tongji Hospital, Tongji Medical University, Wuhan;(4) Present address: Xiehe Hospital, The Hematologic Institution, Wuhan |
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| Abstract: | Summary Immunologically mediated aplastic anemia in mice were used as animal models to study the the curative effect of Zaizhang-I
in term of the changes of two pathogenetic aspects in aplastic mice, namely the defciency of hematopoietic stem cells and
the disturbance of immunology. Our results demonstrated that in aplastic mice, after treatment by Zaizhang-I, the loss of
mature hematopoietice cells (WBC, RBC, Plt) were reduced, and marrow cellular cytosis, and their clinical findings were improved,
indicating a partial remission. The present data show that its curative mechanism lies in the action of promoting the recovery
of colony forming unit-spleen (CFU-S) and reversing immunologically-induced plasma colony forming unit granulocyte/macrophage
(CFU-GM) inhibitory activity. Natural killer cells activity (Nka) and interleukin-2 tumor necrosis factors (TNF) were also
examined to further understand the mechanism by which Zaizhang-I reverse plasma hematopoietic activity. |
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| Keywords: | aplastic anemia mice model Zhaizhang-I plasma hematopoietic inhibitory activity |
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