Persistent reactivable latent herpes simplex virus infection in trigeminal ganglia of mice treated with antiviral drugs |
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| Authors: | B. Svennerholm A. Vahlne E. Lycke |
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| Affiliation: | (1) Department of Virology, Institute of Medical Microbiology, University of Göteborg, Sweden |
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| Abstract: | Summary Latent reactivable infection was established with HSV in mouse trigeminal ganglion. A number of antiviral drugs (IUDR, acycloguanosine, Ara-A, PAA and PFA), effective against acute CNS infection with HSV, failed to influence the latent infection once established. Neither lipophilic properties of PFA-derivatives nor the combination of Ara-A and acyloguanosine improved the drug-effects on HSV latency.With 1 Figure |
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