| Microarray expression analysis of epithelial ovarian cancer with distinct differentiation |
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| 引用本文： | 李艳红 张伟 朱少君 尹国武 闫凯麟 赵宏喜. Microarray expression analysis of epithelial ovarian cancer with distinct differentiation[J]. 中国人民解放军军医大学学报, 2007, 22(6): 373-375. DOI: 10.1016/S1000-1948(08)60021-0 |
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| 作者姓名： | 李艳红 张伟 朱少君 尹国武 闫凯麟 赵宏喜 |
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| 作者单位： | [1]Department of Obstetrics and Gynaecology, Tangdu Hospital, Fourth Military Medical University, Xi＇an710038, China [2]Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi＇an 710038, China |
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| 摘 要： | To identify gene expression profiling in epithelial ovarian cancer and to explore its correlation with histopathology characterization and prognosis. Gene expression profiles were generated from 10 hu- man ovarian frozen tissue specimens using Agilent Human 1A microarrays. Strikingly, clear differences of gene expression patterns were observed in ovarian cancer as compared to normal tissues. Unique gene pro- files were observed in moderately and poorly differentiated epithelial ovarian cancer. It is concluded that different histopathology characterization likely exists extensive molecular heterogeneity.
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| 关 键 词： | 卵巢癌 微阵列表达分析 上皮组织 组织病理学 |
| 收稿时间： | 2007-09-20 |
| 修稿时间： | 2007-11-20 |
Microarray expression analysis of epithelial ovarian cancer with distinct differentiation |
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| LI Yan-hong,ZHANG Wei,ZHU Shao-jun,YIN Guo-wu,YAN Kai-lin,ZHAO Hong-xi. Microarray expression analysis of epithelial ovarian cancer with distinct differentiation[J]. Journal of Medical Colleges of PLA(China), 2007, 22(6): 373-375. DOI: 10.1016/S1000-1948(08)60021-0 |
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| Authors: | LI Yan-hong ZHANG Wei ZHU Shao-jun YIN Guo-wu YAN Kai-lin ZHAO Hong-xi |
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| Affiliation: | LI Yan-hong, ZHANG Wei, ZHU Shao-jun,YIN Guo-wu, YAN Kai-lin, ZHAO Hong-xi(Department of Obstetrics and Gynaecology, Tangdu Hospital, Fourth Military Medical University, Xi＇an 710038, China ZDepartment of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi＇an 710038, China) |
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| Abstract: | To identify gene expression profiling in epithelial ovarian cancer and to explore its correlation with histopathology characterization and prognosis. Gene expression profiles were generated from 10 hu- man ovarian frozen tissue specimens using Agilent Human 1A microarrays. Strikingly, clear differences of gene expression patterns were observed in ovarian cancer as compared to normal tissues. Unique gene pro- files were observed in moderately and poorly differentiated epithelial ovarian cancer. It is concluded that different histopathology characterization likely exists extensive molecular heterogeneity. |
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| Keywords: | ovarian cancer microarray differentiation |
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