诱导间充质干细胞向心肌细胞分化方法及分化机制进展

干细胞在体外特定条件下,可特异的向某种组织类型细胞进行分化,其中包括向心肌细胞分化。目前,胚胎干细胞(em-bryonic stem cells,ESCs)虽然具有这方面的功能,且其分化效率较一般成体细胞高,但是由于伦理问题限制了其在临床的应用。而间充质干细胞(mesenchymal stem cells,MSCs)不仅取材方便,且没有伦理争议,是最具希望的再生医学种子细胞,引起了人们的极大关注。目前对于体外诱导不同来源的间充质干细胞向心肌细胞分化方法的实验研究很多,主要包括化学试剂诱导和模拟体内微环境诱导两大类。该文就MSCs向心肌分化的体外诱导方法和分化机制的研究进展作一综述。

Research advances in induction method and mechanism of mesenchymal stem cells differentiation towards cardiomyocyte

Stem cells can be specified to a type of orgar/ization of cells undergoing differentiation in vitro, including differentiation into cardiomyocytes. Embryonic stem cells have this function, and its differentiation rate is generally higher. But ethical problems limit its clin ical application. However, the mesen.chymal stem cell is easy to obtain, and has no ethical controversy, which is one of the most promising seed ceils for regenerative medicine. At present, there are many methods of inducing different sources of mesenchymal stem cells into car diomyocyte, including chemical induction and microenvironment factors induction. This article is mainly on induction method and differen tiation mechanism of the MSCs differentiation towards cardiomyocytes in vitro.