屈光参差性弱视同步记录多焦视觉诱发电位和多焦视网膜电图的对比研究

目的探讨弱视发病的可能机制。方法采用VERIS Science^TM4．2多焦电生理系统对24例屈光参差性弱视患者双眼分别进行多焦图形视觉诱发电位(VEP)、视网膜电图(ERG)同步记录和多焦闪光VEP、ERG同步记录,并与30例正常对照的结果进行比较。结果在不同视网膜区域弱视眼多焦图形VEP、ERG反应和多焦闪光VEP、ERG二阶反应振幅均降低,VEP特征峰潜时延长,ERG潜时无改变。弱视眼多焦闪光一阶反应VEP、ERG的反应振幅密度均降低,潜时无明显改变。多焦图形VEP波形异常程度中心区大于周边区,且与弱视眼的视力异常程度有相关性。弱视眼多焦图形和闪光二阶反应的视网膜．皮层传导时间(RCT)显著延长,闪光一阶反应RCT三组无明显差异。结论弱视眼的mVEP和mERG具有明显的特征性改变,表明弱视眼的视网膜、视觉传导通路和视皮层都存在明显损害,且中心区损害重于周边区,中枢损害重于视网膜。(中华眼科杂志,2005,41：41-46)

Study on anisometropic amblyopia by simultaneously recording multifocal VEP and multifocal ERG

Objective To investigate the characteristic changes of the retina, the visual pathway and the visual cortex in patients with anisometropic amblyopia by simultaneously recording multifocal VEP and multifocal ERG. Methods Pattern and flash simultaneously recording of the multifocal VEP and ERG of both eyes of 24 anisometropic amblyopes were recorded and the results were compared with those of 30 normal subjects. Results In different retinal areas the amplitudes of multifocal pattern VEP and ERG and second order kernel of multifocal flash VEP and ERG of the amblyopic eyes were reduced. In amblyopic eyes the latencies of mVEP were markedly prolonged while no changes of the mERG latencies were found. Amplitudes of first order kernel of multifocal flash VEP and ERG in amblyopic eyes were reduced while no changes in latencies. The abnormalities of multifocal pattern VEP waveforms in amblyopia were larger in central area than in peripheral and were correlated with the damage of visual acuity of the amblyopic eyes. Retinocortical time of multifocal pattern and the second order kernel of multifocal flash responses were prolonged in amblyopic eyes, while no changes were found for the first order kernel responses. Conclusion~The mVEP and mERG results reveiled characteristic suggesting a malfunction of the retina,the visual pathway and the visual cortex in amblyopic patients.