氟比洛芬酯复合芬太尼用于术后自控静脉镇痛的临床研究

目的观察氟比洛芬酯复合芬太尼用于术后患者自控静脉镇痛的效果和不良反应。方法择期腹部手术患者80例，随机数字表法分为实验组和对照组各40例：实验组术毕静脉注射氟比洛芬酯50mg为负荷剂量后接PCA泵，泵内药按随机数字表法将物为氟比洛芬酯50mg＋芬太尼0．5mg＋氟哌利多5mg＋生理盐水至100ml；对照组术毕静脉注射芬太尼0．1mg为负荷剂量后接PCA泵，泵内药物为芬太尼1．2mg＋氟哌利多5mg＋生理盐水至100ml。记录术后4、12、24h镇痛评分、镇静评分及不良反应。分别于术前，术后即刻和24h测凝血酶原时间、激活部分凝血酶原时间、纤维蛋白原、血小板计数及平均血小板体积。结果2组镇痛效果和凝血功能的差异无统计学意义（P〉0．05），实验组镇静度和恶心呕吐等不良反应的发生率明显低于对照组（P〈0．05）。凝血功能相关指标比较，差异无统计学意义（P〉0．05）。结论氟比洛芬酯复合芬太尼用于术后静脉自控镇痛，镇痛效果满意，且不良反应发生率低。

Effective of flurbiprofen axetil with fentanyl for postoperative patient controlled intravenous analgesia

Objective To study the effect and side effect of flurbiprefen axetil combined with fentanyl for postoperative patient-controlled intravenous analgesia (PCIA). Methods Eighty patients undergoing scheduled abdominal surgery were randomly divided into two groups (n = 40). In treatment group(flurbiprofen axetil 50 mg + fentanyl 0.5 mg+ droperidol 5 mg/100 ml), the loading dose was flurbiprofen axetil 50 mg prior to the PCA. In control group (fentanyl 1.2 mg+ droperidol 5 mg/100 ml) ,the loading dose was fentanyl 0.1 mg prior to the PCA.The visual analog scale(VAS)and the sedative scores (SS) were evaluated in 4 h, 12 h and 24 h aftert treatment. The values of prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen (FIB), platelet (PLT) and mean platelet volume(MPV) were measured before operation,after instantly operation and 24 hours after opreration. Results There was no significant difference in VAS and coagnlative blood function between two groups (P>0.05). The SS scores, nausea and vomiting in control group were significantly more than those in treatment group(P<0.05). Conclusion Co-administration of flurbiprofen axetil and fentanyl provides good and safe analgesia effect.