Lactoferrin-mediated protection of the host from murine cytomegalovirus infection by a T-cell-dependent augmentation of natural killer cell activity |
| |
Authors: | K. Shimizu H. Matsuzawa K. Okada S. Tazume S. Dosako Y. Kawasaki K. Hashimoto Y. Koga |
| |
Affiliation: | (1) Department of Infectious Diseases, Tokai University School of Medicine, Kanagawa, Japan;(2) Technical Research Institute, Snow Brand Milk Products Co, Saitama, Japan;(3) Present address: Department of Nursing, Tokai University School of Health Sciences, Kanagawa, Japan |
| |
Abstract: | Summary The administration of bovine lactoferrin (LF) with 1 mg/g body weight before the murine cytomegalovirus (MCMV) infection completely protected the BALB/c mice from death due to the infection. In these LF-treated mice, a significant increase in the activity was found in the NK cells but not in the cytolytic T lymphocytes which recognized an MCMV-derived peptide. Moreover, the elimination of the NK cell activity by an injection with anti-asialo GM1 antibody abrogated such augmented resistance, thus supporting the hypothesis that the LF-mediated antiviral effect in vivo is performed through the augmentation of NK cell activity. No such LF-mediated antiviral effect in vivo with the increased NK cell activity was found in athymic nude mice, whereas it was restored completely by the transfer of splenic T cells from LF-treated donors. These findings therefore suggest that T lymphocytes induce both the augmentation of NK cell activity and the resultant antiviral effect in the LF-treated hosts. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|