地尔硫和硝酸异山梨酯静脉注射治疗不稳定性心绞痛的比较

目的 :比较地尔硫与硝酸异山梨酯注射液治疗不稳定性心绞痛疗效及安全性。方法 :心绞痛病人 90例 ,分为地尔硫组 4 2例 ,以地尔硫注射液 5 0mg加入氯化钠注射液 2 5 0mL中 ,10～ 15mg·h- 1,drip ,qd× 7d。硝酸异山梨酯组 4 8例 ,以硝酸异山梨酯 2 0mg加入氯化钠注射液 2 5 0mL ,2 .5～ 4mg·h- 1,drip ,qd× 7d。结果 :地尔硫组总有效率为 81% ,心电图总有效率为 74 % ,硝酸异山梨酯组总有效率为 74 % ,心电图总有效率为65 % ,2组间差别无显著意义 (P >0 .0 5 )。但在自发性心绞痛中 ,地尔硫组较硝酸异山梨酯组胸痛次数明显减少 ,ST段变化也有改善。随访 2mo ,2组心血管事件无显著差异。结论 :地尔硫与硝酸异山梨酯注射液治疗不稳定性心绞痛疗效相近 ,对自发性心绞痛效果可能更明显

Diltiazem vs isosorbide dinitrate in intravenous treating in patient with unstable angina pectoris

AIM:To compare the effects of dilitiazem and isosorbide dinitrate in treating patients with unstable angina pectoris. METHODS: Ninty patients with unstable angina pictoris were divided into two groups. Group dilitiazem of 42 patients (M 30, F 12; age 65 a±11 a) was given diltiazem injection 50 mg(added in 0.9% sodium chloride injection 250 mL) iv, gtt, qd×7 d. Group isosorbide dinitrate of 48 patients (M 35, F 13; age 68 a±9 a) was given isosorbide dinitrate injection 20 mg(added in 0.9% sodium chloride injection 250 mL) iv, gtt, qd×7 d. RESULTS: In group diltiazem, the total effective raties were 81% and 74%. In group isosorbide dinitrate the total effective rates were 74% and 65%. In both groups, the later rate was shown by electrocardiophy and there was no differenece. In group diltiazem, the effective rate was better than that in group isosorbide dinitrate. By 2 mo following up, nearly the same cardiovescular accidence occured in both groups. CONCLUSION: There is nearly the same therapy effectiveness both in group isosorbide dinitrate and group diltiazem, and it is more effective in patients suffered from spontaneous angina pectoris by using diltiazem.